Rifampicin kinetics in undernutrition.

The effect of rifampicin on piroxicam kinetics.

Rifampicin is known to influence the metabolic disposition of other drugs because of its 'enzyme inducing' effects in the liver (1, 6). The microsomal enzymes catalyze glucuronide conjugations and most of the oxidation of the drugs. Reduction and hydrolysis of drugs are catalyzed by both microsomal and non-microsomal enzymes (3). Hydroxylation and glucuronide formation are involved in the metab...

Sulfur amino acid metabolism in children with severe childhood undernutrition: methionine kinetics.

BACKGROUND Children with edematous but not nonedematous severe childhood undernutrition (SCU) have lower plasma and erythrocyte-free concentrations of cysteine and methionine, which suggests a decreased availability of methionine for cysteine synthesis. We propose that methionine production and metabolism will be slower in children with edematous SCU than in those with nonedematous SCU. OBJEC...

Child Undernutrition in India

Undernutrition in older adults.

Undernutrition in older persons usually presents as weight loss and is predominantly due to protein energy wasting. The presentation of undernutrition is often subtle in older persons and there is a need to utilize screening tools and increasing physician awareness. There are multiple treatable causes of undernutrition in older persons. The major causes are anorexia, cachexia, sarcopenia, dehyd...

Undernutrition in hospital patients.

Undernutrition is a serious condition affecting significant numbers of patients in hospital. It increases the risk of mortality, delays recovery and increases the cost of hospitalisation. The prevention of undernutrition in hospital patients should be a priority for all healthcare professionals and requires a collaborative multidisciplinary approach.